Accuracy of genomic selection using different methods to define haplotypes

282Citations
Citations of this article
421Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Genomic selection uses total breeding values for juvenile animals, predicted from a large number of estimated marker haplotype effects across the whole genome. In this study the accuracy of predicting breeding values is compared for four different models including a large number of markers, at different marker densities for traits with heritabilities of 50 and 10%. The models estimated the effect of (1) each single-marker allele [single-nucleotide polymorphism (SNP)1], (2) haplotypes constructed from two adjacent marker alleles (SNP2), and (3) haplotypes constructed from 2 or 10 markers, including the covariance between haplotypes by combining linkage disequilibrium and linkage analysis (HAP_IBD2 and HAP_IBD10). Between 119 and 2343 polymorphic SNPs were simulated on a 3-M genome. For the trait with a heritability of 10%, the differences between models were small and none of them yielded the highest accuracies across all marker densities. For the trait with a heritability of 50%, the HAP_IBD10 model yielded the highest accuracies of estimated total breeding values for juvenile and phenotyped animals at all marker densities. It was concluded that genomic selection is considerably more accurate than traditional selection, especially for a low-heritability trait. Copyright © 2008 by the Genetics Society of America.

Cite

CITATION STYLE

APA

Calus, M. P. L., Meuwissen, T. H. E., De Roos, A. P. W., & Veerkamp, R. F. (2008). Accuracy of genomic selection using different methods to define haplotypes. Genetics, 178(1), 553–561. https://doi.org/10.1534/genetics.107.080838

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free