Acoustic droplet vaporization for temporal and spatial control of tissue occlusion: A kidney study

  • Kripfgans O
  • Orifici C
  • Carson P
 et al. 
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Abstract

Acoustic droplet vaporization (ADV) has been introduced with the potential application of tumor treatment via occlusion and subsequent necrosis. New Zealand White rabbits were anesthetized, and their left kidney was externalized. An imaging array and single-element transducer were positioned in a tank with direct access to the kidney's vasculature and renal artery. Filtered droplet emulsions (diameter 90% and an average organ perfusion reduction of >70% was achieved using ADV. After treatment of the left kidney, the control kidney on the contralateral side showed a maximum decrease in regional blood flow of 18% relative to the pre-ADV baseline. Image-based hyper-echogenicity from ADV of IA injections was monitored for approximately 90 minutes, and cortex perfusion was reduced by >60% of its original value for more than 1 hour. This could be enough time for the onset of cell death and possible tumor treatment via ischemic necrosis. Moreover, currently used radiofrequency tissue ablation-based tumor treatment could benefit from ADV due to the decreased heat loss via vascular cooling.

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Authors

  • Paul CarsonUniversity of Michigan Medical School

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  • Oliver D. Kripfgans

  • Catherine M. Orifici

  • Kimberly A. Ives

  • O. Petter Eldevik

  • J. Brian Fowlkes

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