Acoustic injury in mice: 129/SvEv is exceptionally resistant to noise-induced hearing loss

  • Yoshida N
  • Hequembourg S
  • Atencio C
 et al. 
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Abstract

129/SvEv is an inbred mouse strain popular for use in genetic knockout studies. Here, we compare normal auditory function and vulnerability to acoustic injury in wild-type mice of the 129/SvEv vs. CBA/CaJ strains. Compound action potentials (CAPs) and distortion product otoacoustic emissions (DPOAEs) showed slightly higher thresholds for 129/SvEv re CBA/CaJ, especially at frequencies >20 kHz. Middle-ear motion (i.e. umbo velocity) was similar in the two strains; although frequencies >20 kHz could not be evaluated. Permanent threshold shift (PTS) and hair cell losses, measured 1 week after high-intensity exposure to an 8-16 kHz noise band, were smaller in129/SvEv at all exposure levels and durations from 97 dB SPLx2 h to 106 dB SPLx8 h. Furthermore, PTS growth with increasing exposure energy was slower in 129/SvEv (

Author-supplied keywords

  • Age-related hearing loss
  • Cochlea
  • Noise-induced hearing loss

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Authors

  • Naohiro Yoshida

  • Stephanie J. Hequembourg

  • Craig A. Atencio

  • John J. Rosowski

  • M. Charles Liberman

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