Acquisition, extinction, and reinstatement of Pavlovian fear conditioning: The roles of the NMDA receptor and nitric oxide

  • Johnson D
  • Baker J
  • Azorlosa J
  • 26

    Readers

    Mendeley users who have this article in their library.
  • 31

    Citations

    Citations of this article.

Abstract

The acquisition and extinction of Pavlovian conditioned fear have been shown to be mediated by the N-methyl-D-aspartate (NMDA) glutamate receptor. This study found that the NMDA antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclo-hepten-5,10-imine maleate (MK-801) blocked the reinstatement of Pavlovian conditioned fear in rats. The role of nitric oxide (NO) in the acquisition and extinction of Pavlovian fear conditioning was also examined. L-NAME, an NO synthase inhibitor, failed to block the acquisition or extinction of Pavlovian fear conditioning. The results are discussed in the context of hierarchical associations and the array of NMDA and calcium mediated mechanisms of synaptic strengthening. Copyright (C) 2000 Elsevier Science B.V.

Author-supplied keywords

  • MK-801
  • NMDA receptor
  • Nitric oxide
  • Pavlovian conditioning
  • Reinstatement

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Deann M. Johnson

  • Jeffrey D. Baker

  • Julian L. Azorlosa

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free