Activity of the hypothalamus-pituitary-adrenal system and oral glucose tolerance in depressed patients

  • Weber-Hamann B
  • Kopf D
  • Lederbogen F
 et al. 
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We hypothesized that the activity of the hypothalamus-pituitary-adrenal system in depressed patients is related to oral glucose tolerance. In 70 moderately depressed inpatients, we measured morning saliva cortisol for 6 days and assessed oral glucose tolerance. We found glucose concentrations to be positively associated with mean morning cortisol concentrations (F3,236 = 2.86, p < 0.05). Also, the ISI, a measure of insulin receptor sensitivity, was negatively associated with mean morning cortisol concentrations (r = -0.25, p < 0.04). These findings support the hypothesis that hypercortisolemia may lead to disturbed glucose utilization in depressed patients.

Author-supplied keywords

  • Adrenal steroids
  • Clinical neuroendocrinology
  • Corticotropin
  • Depression
  • Glucose tolerance
  • Insulin
  • Insulin receptors

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  • Bettina Weber-Hamann

  • Daniel Kopf

  • Florian Lederbogen

  • Maria Gilles

  • Isabella Heuser

  • Michael Colla

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