Acute and chronic suppression of the central ghrelin signaling system reveals a role in food anticipatory activity

  • Verhagen L
  • Egecioglu E
  • Luijendijk M
 et al. 
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Using the rodent activity-based anorexia (ABA) model that mimics clinical features of anorexia nervosa that include food restriction-induced hyperlocomotion, we found that plasma ghrelin levels are highly associated with food anticipatory behaviour, measured by running wheel activity in rats. Furthermore, we showed that ghrelin receptor (GHS-R1A) knockout mice do not anticipate food when exposed to the ABA model, unlike their wild type littermate controls. Likewise, food anticipatory activity in the ABA model was suppressed by a GHS-R1A antagonist administered either by acute central (ICV) injection to rats or by chronic peripheral treatment to mice. Interestingly, the GHS-R1A antagonist did not alter food intake in any of these models. Therefore, we hypothesize that suppression of the central ghrelin signaling system via GHS-R1A provides an interesting therapeutic target to treat hyperactivity in patients suffering from anorexia nervosa. © 2010.

Author-supplied keywords

  • Activity-based anorexia
  • Food anticipatory activity
  • GHS-R1A antagonist
  • Ghrelin
  • JMV2959
  • Running wheel activity

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  • Linda A W Verhagen

  • Emil Egecioglu

  • Mieneke C M Luijendijk

  • Jacquelien J G Hillebrand

  • Roger A H Adan

  • Suzanne L. Dickson

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