Using the rodent activity-based anorexia (ABA) model that mimics clinical features of anorexia nervosa that include food restriction-induced hyperlocomotion, we found that plasma ghrelin levels are highly associated with food anticipatory behaviour, measured by running wheel activity in rats. Furthermore, we showed that ghrelin receptor (GHS-R1A) knockout mice do not anticipate food when exposed to the ABA model, unlike their wild type littermate controls. Likewise, food anticipatory activity in the ABA model was suppressed by a GHS-R1A antagonist administered either by acute central (ICV) injection to rats or by chronic peripheral treatment to mice. Interestingly, the GHS-R1A antagonist did not alter food intake in any of these models. Therefore, we hypothesize that suppression of the central ghrelin signaling system via GHS-R1A provides an interesting therapeutic target to treat hyperactivity in patients suffering from anorexia nervosa. © 2010.
CITATION STYLE
Verhagen, L. A. W., Egecioglu, E., Luijendijk, M. C. M., Hillebrand, J. J. G., Adan, R. A. H., & Dickson, S. L. (2011). Acute and chronic suppression of the central ghrelin signaling system reveals a role in food anticipatory activity. European Neuropsychopharmacology, 21(5), 384–392. https://doi.org/10.1016/j.euroneuro.2010.06.005
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