Acute exercise induces FGF21 expression in mice and in healthy humans.

  • Kim K
  • Kim S
  • Min Y
 et al. 
  • 17


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Fibroblast growth factor 21 (FGF21) plays an important role in the regulation of energy homeostasis during starvation and has an excellent therapeutic potential for the treatment of type 2 diabetes in rodents and monkeys. Acute exercise affects glucose and lipid metabolism by increasing glucose uptake and lipolysis. However, it is not known whether acute exercise affects FGF21 expression. Here, we showed that serum FGF21 level is increased in mice after a single bout of acute exercise, and that this is accompanied by increased serum levels of free fatty acid, glycerol and ketone body. FGF21 gene expression was induced in the liver but not in skeletal muscle and white adipose tissue of mice after acute exercise, and further, the gene expression levels of hepatic peroxisome proliferator-activated receptor α (PPARα) and activating transcription factor 4 (ATF4) were also increased. In addition, we observed increased FGF21 level in serum of healthy male volunteers performing a treadmill run at 50 or 80% VO2max. These results suggest that FGF21 may also be associated with exercise-induced lipolysis in addition to increased catecholamines and reduced insulin.

Author-supplied keywords

  • Activating Transcription Factor 4
  • Activating Transcription Factor 4: metabolism
  • Animals
  • Exercise
  • Fibroblast Growth Factors
  • Fibroblast Growth Factors: blood
  • Fibroblast Growth Factors: genetics
  • Gene Expression Regulation
  • Health
  • Humans
  • Liver
  • Liver: metabolism
  • Male
  • Mice
  • Mice, Inbred C57BL
  • PPAR alpha
  • PPAR alpha: metabolism
  • Physical Conditioning, Animal
  • Young Adult

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Kook Hwan Kim

  • Seong Hun Kim

  • Young-Ki Min

  • Hun-Mo Yang

  • Jeong-Beom Lee

  • Myung-Shik Lee

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free