Acute hemodynamic effects of caffeine administration in premature infants

  • V. S
  • A. B
  • A. I
 et al. 
  • 1

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

Objective: Administration of caffeine citrate (caffeine) has been a central component of the treatment of apnea of prematurity. However, given its multiple pharmacologic effects, caffeine might be expected to produce hemodynamic changes in heart rate, stroke volume, cardiac output and vascular resistance. Study Design: In this prospective observational study, we report the hemodynamic effects of intravenous caffeine administration in a population of premature infants who received caffeine to correct or prevent apnea of prematurity. Methods: Hemodynamic effects of caffeine were determined in 31 infants. Stroke volume was measured via echocardiogram, using velocity time integral at the aortic root diameter. Statistically univariate analyses were performed parametrically using paired t-test and nonparametrically (sign test). Multivariate linear regression models were used to identify subgroup covariate effects. Results: After intravenous caffeine, cardiac index increased in 31 of 31 trials, by an average of 14.6 +/- 16.3% (s.d.); stroke volume increased in 24 of 31 trials, by 7.8 +/- 12.2%; heart rate increased in 28 of 31 trials by 7.7 +/- 7.2beats per min; and blood pressure increased in 25 of 31 trials, by 4.1 +/- 5.8mmHg (all P

Author-supplied keywords

  • *caffeine citrate/ct [Clinical Trial]
  • *caffeine citrate/do [Drug Dose]
  • *caffeine citrate/dt [Drug Therapy]
  • *caffeine citrate/iv [Intravenous Drug Administrat
  • *caffeine citrate/pd [Pharmacology]
  • *heart hemodynamics
  • *newborn apnea/dt [Drug Therapy]
  • *newborn apnea/pc [Prevention]
  • article
  • birth weight
  • blood pressure
  • clinical article
  • clinical trial
  • continuous infusion
  • controlled clinical trial
  • controlled study
  • dose response
  • drug activity
  • drug dose comparison
  • drug efficacy
  • drug mechanism
  • echocardiography
  • gestational age
  • heart beat
  • heart index
  • heart output
  • heart rate
  • heart stroke volume
  • human
  • infant
  • maternal age
  • outcome assessment
  • prematurity

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Soloveychik V.

  • Bin-Nun A.

  • Ionchev A.

  • Sriram S.

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free