Acute toxicity and genotoxicity of two novel pesticides on amphibian, Rana N. Hallowell

  • Feng S
  • Kong Z
  • Wang X
 et al. 
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Imidacloprid [1-(6-chloro-3-pyridylmethyl)-N-nitro-imidazolidin-2- ylideneamine] and RH-5849 [2′-benzoyl-l′-tert- butylbenzoylhydrazinel] are two pesticides used in China since 1992. In the present study we conducted acute toxicity test, micronucleus (MN) test and comet assay of the two pesticides on amphibian, Rana N. Hallowell, a sensitive organism suitable for acting as the bio-indicator of aquatic and agricultural ecosystems. The values of LC50-48 h of imidacloprid were found to be 165 mgl-1for tadpoles of Rana limnocharis and 219 mgl-1for tadpoles of Rana N. Hallowell. On the other hand, RH-5849 showed no acute toxicity to tadpoles during the 96 h exposure even it was saturated in the test solutions. There were significant differences in the MN frequencies between the negative controls and the treated groups at the dose of 8 mgl-1for imidacloprid (p

Author-supplied keywords

  • Comet assay
  • Genotoxicity
  • Imidacloprid
  • Micronucleus
  • RH-5849
  • Rana N. Hallowell

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  • Shaolong Feng

  • Zhiming Kong

  • Xinming Wang

  • Lirong Zhao

  • Pingan Peng

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