Acyclic amino acid-catalyzed direct asymmetric aldol reactions: alanine, the simplest stereoselective organocatalyst

  • Córdova A
  • Zou W
  • Ibrahem I
 et al. 
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Abstract

The linear amino acid-catalyzed direct asymmetric intermolecular aldol reaction is presented; simple amino acids such as alanine, valine, isoleucine, aspartate, alanine tetrazole and serine catalyzed the direct catalytic asymmetric intermolecular aldol reactions between unmodified ketones and aldehydes with excellent stereocontrol and furnished the corresponding aldol products in up to 98% yield and with up to > 99% ee.

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Authors

  • Armando Córdova

  • Weibiao Zou

  • Ismail Ibrahem

  • Efraim Reyes

  • Magnus Engqvist

  • Wei-Wei Liao

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