Addressing the challenges of multiscale model management in systems biology

  • Hetherington J
  • Bogle I
  • Saffrey P
 et al. 
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Mathematical and computational modelling are emerging as important techniques for studying the behaviour of complex biological systems. We argue that two advances are necessary to properly leverage these techniques: firstly, the ability to integrate models developed and executed on separate tools, without the need for substantial translation and secondly, a comprehensive system for storing and man-ageing not only the models themselves but also the parameters and tools used to execute those models and the results they produce. A framework for modelling with these features is described here. We have developed of a suite of XML-based services used for the storing and analysis of models, model parameters and results, and tools for model integration. We present these here, and evaluate their effectiveness using a worked example based on part of the hepatocyte glycogenolysis system. (c) 2006 Elsevier Ltd. All rights reserved.

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  • J Hetherington

  • IDL Bogle

  • P Saffrey

  • O Margoninski

  • L Li

  • MV Rey

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