Adiponectin acts as a positive indicator of left ventricular diastolic dysfunction in patients with hypertrophic cardiomyopathy.

  • Morikawa M
  • Sato H
  • Koretsune Y
 et al. 
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BACKGROUND: Adiponectin is an adipose-derived plasma protein that exhibits beneficial actions on the heart. Recently, it was shown that adiponectin levels were elevated in patients with systolic heart failure. OBJECTIVE: To investigate the association between adiponectin levels and left ventricular (LV) diastolic function in patients with hypertrophic cardiomyopathy (HCM), characterised by diastolic dysfunction. METHODS: Twenty-six patients with HCM showing LV ejection fraction of >60% were enrolled. LV pressure half-time (T(1/2)) was measured as an index of myocardial relaxation. Patients were divided into two groups on the basis of baseline T(1/2) (group A: T(1/2) or = 35 ms). Blood samples were simultaneously collected from the coronary sinus (CS) and aortic root (Ao) as well as the peripheral vein (PV) for measurement of plasma adiponectin levels. RESULTS: Plasma adiponectin levels were significantly higher in group B than in group A. Adiponectin levels in the PV were positively correlated with the baseline T(1/2) in patients with HCM. The transcardiac gradient of adiponectin as calculated by the Ao-CS difference was significantly higher in group A than in group B. The transcardiac gradient of adiponectin also inversely correlated with the baseline T(1/2) and adiponectin levels in PV in patients with HCM. The expression of AdipoR1 but not AdipoR2 in the heart decreased in group B. The baseline T(1/2) was negatively associated with AdipoR1 expression in patients with HCM. CONCLUSIONS: These data document that adiponectin is an indicator of LV diastolic dysfunction in patients with HCM.

Author-supplied keywords

  • adiponectin
  • adiponectin blood
  • aorta
  • biological markers
  • biological markers blood
  • cardiomyopathy
  • coronary sinus
  • coronary sinus metabolism
  • diastole
  • diastole physiology
  • female
  • humans
  • hypertrophic
  • hypertrophic blood
  • hypertrophy
  • left
  • left blood
  • left ventricular
  • left ventricular blood
  • male
  • middle aged
  • stroke volume
  • stroke volume physiology
  • thoracic
  • thoracic metabolism
  • veins
  • veins metabolism
  • ventricular dysfunction

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  • M Morikawa

  • H Sato

  • Y Koretsune

  • Y Ohnishi

  • T Kurotobi

  • T Kuzuya

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