Adjunct prednisone therapy for patients with community-acquired pneumonia: a multicentre, double-blind, randomised, placebo-controlled trial

  • Blum C
  • Nigro N
  • Briel M
 et al. 
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METHODSIn this double-blind, multicentre, randomised, placebo-controlled trial, we recruited patients aged 18 years or older with community-acquired pneumonia from seven tertiary care hospitals in Switzerland within 24 h of presentation. Patients were randomly assigned (1:1 ratio) to receive either prednisone 50 mg daily for 7 days or placebo. The computer-generated randomisation was done with variable block sizes of four to six and stratified by study centre. The primary endpoint was time to clinical stability defined as time (days) until stable vital signs for at least 24 h, and analysed by intention to treat. This trial is registered with, number NCT00973154.FINDINGSFrom Dec 1, 2009, to May 21, 2014, of 2911 patients assessed for eligibility, 785 patients were randomly assigned to either the prednisone group (n=392) or the placebo group (n=393). Median time to clinical stability was shorter in the prednisone group (3·0 days, IQR 2·5-3·4) than in the placebo group (4·4 days, 4·0-5·0; hazard ratio [HR] 1·33, 95% CI 1·15-1·50, p

Author-supplied keywords

  • Aged, 80 and over[checkword]
  • Aged[checkword]
  • Anti-Bacterial Agents [therapeutic use]
  • Anti-Inflammatory Agents [administration & dosage]
  • Community-Acquired Infections [drug therapy] [micr
  • Double-Blind Method
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Female[checkword]
  • Hospitalization
  • Humans[checkword]
  • Intention to Treat Analysis
  • Male[checkword]
  • Middle Aged[checkword]
  • Pneumonia [drug therapy] [microbiology]
  • Prednisone [administration & dosage]
  • Switzerland
  • Treatment Outcome

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  • Ca Blum

  • N Nigro

  • M Briel

  • P Schuetz

  • E Ullmer

  • I Suter-Widmer

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