The administration of dextrose during in-hospital cardiac arrest is associated with increased mortality and neurologic morbidity

  • Peng T
  • Andersen L
  • Saindon B
 et al. 
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Abstract

INTRODUCTION: Dextrose may be used during cardiac arrest resuscitation to prevent or reverse hypoglycemia. However, the incidence of dextrose administration during cardiac arrest and the association of dextrose administration with survival and other outcomes are unknown.

METHODS: We used the Get With The Guidelines®-Resuscitation national registry to identify adult patients with an in-hospital cardiac arrest between the years 2000 and 2010. To assess the adjusted effects of dextrose administration on survival, we used multivariable regression models with adjustment for multiple patient, event, and hospital characteristics. We performed additional analyses to examine the effects of dextrose on neurological outcome and return of spontaneous circulation.

RESULTS: Among the 100,029 patients included in our study, 4,189 (4.2%) received dextrose during cardiac arrest resuscitation. The rate of dextrose administration increased during the study period (odds ratio 1.11, 95% confidence interval (CI) 1.09-1.12 per year, P
CONCLUSIONS: In this dataset, the administration of dextrose during resuscitation in patients with in-hospital cardiac arrest was found to be associated with a significantly decreased chance of survival and a decreased chance of good neurological outcome.

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Authors

  • Teng J. Peng

  • Lars W. Andersen

  • Brian Z. Saindon

  • Tyler A. Giberson

  • Won Young Kim

  • Katherine Berg

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