The 'adrenaline hypothesis' of hypertension revisited: Evidence for adrenaline release from the heart of patients with essential hypertension

  • Rumantir M
  • Jennings G
  • Lambert G
 et al. 
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Abstract

Whether adrenaline acts as a sympathetic nervous cotransmitter in humans and stimulates beta2-adrenoceptors to augment neuronal noradrenaline release remains a subject of considerable dispute. The aim of this study was to test if adrenaline is released from regional sympathetic nerves (in the heart) in patients with essential hypertension, and to investigate whether locally released adrenaline might enhance cardiac noradrenaline release.

Author-supplied keywords

  • Cotransmitter
  • Heart
  • Noradrenaline
  • Sympathetic nervous system
  • β-adrenoceptors

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Authors

  • Magdalena S. Rumantir

  • Garry L. Jennings

  • Gavin W. Lambert

  • David M. Kaye

  • Douglas R. Seals

  • Murray D. Esler

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