Adult neural stem cells in the mammalian central nervous system.

  • Ma D
  • Bonaguidi M
  • Ming G
 et al. 
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Abstract

Neural stem cells (NSCs) are present not only during the embryonic
development but also in the adult brain of all mammalian species,
including humans. Stem cell niche architecture in vivo enables adult
NSCs to continuously generate functional neurons in specific brain
regions throughout life. The adult neurogenesis process is subject
to dynamic regulation by various physiological, pathological and
pharmacological stimuli. Multipotent adult NSCs also appear to be
intrinsically plastic, amenable to genetic programing during normal
differentiation, and to epigenetic reprograming during de-differentiation
into pluripotency. Increasing evidence suggests that adult NSCs significantly
contribute to specialized neural functions under physiological and
pathological conditions. Fully understanding the biology of adult
NSCs will provide crucial insights into both the etiology and potential
therapeutic interventions of major brain disorders. Here, we review
recent progress on adult NSCs of the mammalian central nervous system,
including topics on their identity, niche, function, plasticity,
and emerging roles in cancer and regenerative medicine.

Author-supplied keywords

  • Adult Stem Cells
  • cytology; Humans; Neurogenesis; Neuronal Plastici
  • pathology/physiology; Cell Differentiation; Centr
  • physiology
  • physiology; Brain

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Authors

  • Dengke K Ma

  • Michael A Bonaguidi

  • Guo-Li Ming

  • Hongjun Song

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