Adult neurogenesis and functional plasticity in neuronal circuits.

  • Lledo P
  • Alonso M
  • M G
  • 28

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Abstract

The adult brain is a plastic place. To ensure that the mature nervous system's control of behaviour is flexible in the face of a varying environment, morphological and physiological changes are possible at many levels, including that of the entire cell. In two areas of the adult brain - the olfactory bulb and the dentate gyrus - new neurons are generated throughout life and form an integral part of the normal functional circuitry. This process is not fixed, but highly modulated, revealing a plastic mechanism by which the brain's performance can be optimized for a given environment. The functional benefits of this whole-cell plasticity, however, remain a matter for debate.

Author-supplied keywords

  • Animals
  • Cell Differentiation
  • Cell Differentiation: physiology
  • Cell Proliferation
  • Dentate Gyrus
  • Dentate Gyrus: cytology
  • Humans
  • Models, Neurological
  • Nerve Net
  • Nerve Net: cytology
  • Nerve Net: physiology
  • Neuronal Plasticity
  • Neuronal Plasticity: physiology
  • Neurons
  • Neurons: physiology
  • Olfactory Bulb
  • Olfactory Bulb: cytology
  • Stem Cells
  • Stem Cells: physiology

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Authors

  • P Lledo

  • M Alonso

  • Grubb M

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