Photodynamic therapy (PDT) has been pioneered in dermatology at the beginning of the 20th century. Today, cutaneous treatments are the most common applications of PDT. Originating from cancer therapy, recent developments have widened the therapeutic spectrum, and now PDT indications range from inflammatory disorders to cosmetic applications. With several photosensitizers approved by regulatory agencies around the world, PDT continues demonstrating its inherent versatility. This review concentrates on aminolevulinic acid-based PDT regimens in dermatology. Recent research has helped to enhance the treatment efficacy of PDT and to further exploit its potential. Evolving strategies are being tested at present experimentally that will increase the power and diversity of cutaneous PDT. Ultimately these regimens will affect future development in clinical applications.
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