Adverse drug reactions in veterinary patients associated with drug transporters.

  • Mealey K
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Abstract

For many drugs used in veterinary practice, plasma and tissue concentrations are highly dependent on the activity of drug transporters. This article describes how functional changes in drug transporters, whether mediated by genetic variability or drug-drug interactions, affect drug disposition and, ultimately, drug safety and efficacy in veterinary patients. A greater understanding of species, breed, and individual (genetic) differences in drug transporter function, as well as drug-drug interactions involving drug transporters, will result in improved strategies for drug design and will enable veterinarians to incorporate individualized medicine in their practices.

Author-supplied keywords

  • ATP-Binding Cassette Transporters
  • ATP-Binding Cassette Transporters: genetics
  • ATP-Binding Cassette Transporters: metabolism
  • Animals
  • Cat Diseases
  • Cat Diseases: chemically induced
  • Cat Diseases: genetics
  • Cat Diseases: metabolism
  • Cats
  • Dog Diseases
  • Dog Diseases: chemically induced
  • Dog Diseases: genetics
  • Dog Diseases: metabolism
  • Dogs
  • Drug-Related Side Effects and Adverse Reactions
  • Drug-Related Side Effects and Adverse Reactions: g
  • Gene Expression Regulation
  • Organic Anion Transporters
  • Organic Anion Transporters: genetics
  • Organic Anion Transporters: metabolism
  • Pharmacogenetics
  • Species Specificity

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Authors

  • Katrina L Mealey

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