Age-related changes of the 3'APOB-VNTR genotype pool in ageing cohorts

  • De Benedictis G
  • Carotenuto L
  • Carrieri G
 et al. 
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The analysis of seven different age cohorts (697 individuals from 10 to 109 years old) revealed age-related changes in the 3'APOB-VNTR genotype pool. By recoding the 3'APOB-VNTR alleles into three size-classes (small, S, 26-34 repeats; medium, M, 35-39 repeats; large, L, 41-55 repeats), an age-related convex trajectory of the frequency of SS homozygotes was found. The frequency of SS in the genotype pool increased from the group aged 10-19 years (3.06 +/- 1.74%) to that aged 40-49 years (8.51 +/- 4.07%). Then it declined reaching the minimum value in centenarians (1.58 +/- 0.90%). The observed trajectory is in agreement with that expected by assuming crossing of mortality curves relevant to subgroups of individuals having different genotypes.

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  • G. De Benedictis

  • L. Carotenuto

  • G. Carrieri

  • M. De Luca

  • E. Falcone

  • G. Rose

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