Age-related gray matter volume changes in the brain during non-elderly adulthood

  • Terribilli D
  • Schaufelberger M
  • Duran F
 et al. 
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Abstract

Previous magnetic resonance imaging (MRI) studies described consistent age-related gray matter (GM) reductions in the fronto-parietal neocortex, insula and cerebellum in elderly subjects, but not as frequently in limbic/paralimbic structures. However, it is unclear whether such features are already present during earlier stages of adulthood, and if age-related GM changes may follow non-linear patterns at such age range. This voxel-based morphometry study investigated the relationship between GM volumes and age specifically during non-elderly life (18-50 years) in 89 healthy individuals (48 males and 41 females). Voxelwise analyses showed significant (p

Author-supplied keywords

  • *Aging/pathology
  • *Brain Mapping
  • Adolescent
  • Adult
  • Age Factors
  • Brain/*pathology
  • Female
  • Functional Laterality
  • Humans
  • Image Processing, Computer-Assisted/methods
  • Magnetic Resonance Imaging/methods
  • Male
  • Middle Aged
  • Regression Analysis
  • Statistics, Nonparametric
  • Young Adult

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Authors

  • D Terribilli

  • M S Schaufelberger

  • F L Duran

  • M V Zanetti

  • P K Curiati

  • P R Menezes

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