Age-related gray matter volume changes in the brain during non-elderly adulthood

  • Terribilli D
  • Schaufelberger M
  • Duran F
 et al. 
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Abstract

Previous magnetic resonance imaging (MRI) studies described consistent age-related gray matter (GM) reductions in the fronto-parietal neocortex, insula and cerebellum in elderly subjects, but not as frequently in limbic/paralimbic structures. However, it is unclear whether such features are already present during earlier stages of adulthood, and if age-related GM changes may follow non-linear patterns at such age range. This voxel-based morphometry study investigated the relationship between GM volumes and age specifically during non-elderly life (18-50 years) in 89 healthy individuals (48 males and 41 females). Voxelwise analyses showed significant (p

Author-supplied keywords

  • Aging
  • Gender
  • Gray matter
  • Insula
  • Limbic system
  • Magnetic resonance imaging
  • Prefrontal cortex
  • Voxel-based morphometry

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