Aktuelle therapie der myasthenia gravis und der autoimmunen myositiden

  • Schneider-Gold C
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Here we characterise modern treatment algorithms for myasthenia gravis and Lambert- Eaton myasthenic syndrome, as well as for dermato and polymyositis and introduce the current principles of escalating therapeutic strategies. Besides glucocorticosteroids, azathioprine is still the standard base line treatment which may be substituted by mycophenolate mofetil, cyclosporine A, tacrolimus, methotrexate or cyclophosphamide in the case of intolerance or lack of therapeutic efficacy. Inmyasthenic crisis, plasmapheresis and/ or immunoadsorption and intravenous immunoglobulins are evidence-based treatment options. In severe dermato- and polymyositis, the role of plasmapheresis is less clear, while intravenous immunoglobulins were shown to improve dermatomyositis. Rituximab is emerging as a new therapeutic option for severe myasthenia gravis and dermatomyositis. Treatment strategies for inclusion body myositis are still ebing discussed controversely. (c) Georg Thieme Verlag KG Stuttgart

Author-supplied keywords

  • Lambert-Eaton myasthenic syndrome
  • Myasthenia gravis
  • Myositis
  • Therapy

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  • Christiane Schneider-Gold

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