Allenyl azide cycloaddition chemistry: Application to the total synthesis of (±)-meloscine

  • Feldman K
  • Antoline J
  • 36

    Readers

    Mendeley users who have this article in their library.
  • 21

    Citations

    Citations of this article.

Abstract

The pentacyclic alkaloid (±)-meloscine was prepared in 19 steps through a reaction sequence that features a putative azatrimethylenemethane intermediate, generated through cascade cyclization of an allenyl azide substrate, to deliver the core azabicyclo[3.3.0]octadiene substructure. Subsequent manipulation of the peripheral functionality then delivered (±)-meloscine.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Ken S. Feldman

  • Joshua F. Antoline

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free