Alteration of choroidal circulation in the foveal region in patients with type 2 diabetes

  • Nagaoka T
  • Kitaya N
  • Sugawara R
 et al. 
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Abstract

Aim: To investigate changes in choroidal blood flow (CBF) in the foveal region in patients with type 2 diabetes. Methods: Laser Doppler flowmetry was used to determine the CBF in the foveal region in 70 patients with type 2 diabetes and 36 age and sex matched healthy subjects (control group). The patients were classified into three groups: 33 patients (33 eyes) with no diabetic retinopathy (NDR), 20 patients (20 eyes) with non-proliferative diabetic retinopathy and no macular oedema (NPDR/MO2), and 17 patients (17 eyes) with NPDR and MO (NPDR/MO+). Optical coherence tomography was also used to measure the foveal thickness. Results: The group averaged CBF values were 13.5 (4.9), 9.4 (2.5), 10.8 (4.8), and 5.6 (2.0) (arbitrary units) in the control, NDR, NPDR/MO2, and NPDR/MO+ groups, respectively. The group averaged CBF values in the NDR group decreased (30.2%; p,0.01) compared with the control group. The average CBF value in the NPDR/MO+ group was also significantly lower (48.2%; p,0.01) compared with that in the NPDR/MO2 group. Conclusion: The CBF in the foveal region significantly decreases in patients with diabetes, especially those with macular oedema. M

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Authors

  • T. Nagaoka

  • N. Kitaya

  • R. Sugawara

  • H. Yokota

  • F. Mori

  • T. Hikichi

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