Altered Processing of Visual Memory in Patients with Mesial Temporal Sclerosis: An fMRI Study

  • Shankar J
  • Ravishankar S
  • Sinha S
 et al. 
  • 3


    Mendeley users who have this article in their library.
  • 2


    Citations of this article.


Hippocampal complex and neocortex play distinct, complementary roles in
processing of memory, which is impaired in patients with mesial temporal
sclerosis (MTS).
Ten right-sided MTS patients and 10 controls were prospectively assessed
by functional Magnetic Resonance Imaging (fMRI) using encoding and
retrieval of visual memory tasks. Image analyses were done using SPM2
and voxels showing activity with T-score > 4 were considered
significant. Two-sample t-test was applied for equality of means and P <
.01 was considered significant. Patterns of activity in both encoding
and retrieval tasks were compared between the patients and controls.
In normal controls, there was activation of bilateral tail of
hippocampus, parhippocampal gyrus, occipital (right > left), right
prefrontal, and inferior frontal region (T-score > 9) during the
encoding of memory and during the retrieval, there was activation of
left inferior frontal region, bilateral parahippocampal gyrus, and
occipital and parietal region (right > left) activity (T-score > 4). In
patients there was activation of bilateral prefrontal (left right),
bilateral inferior parietal lobule (right left), and bilateral
parieto-occipital lobe activity(T-score > 4) during encoding and there
was comparatively less activation (T-score > 3) of bilateral inferior
parietal lobule (left right) and bilateral prefrontal (right left)
regions during retrieval.
Visual memory processing is affected and altered in patients with MTS.
Reallocation of visual memory processing is observed in patients with
MTS suggesting different networking.

Author-supplied keywords

  • Functional MRI
  • Mesial temporal lobe epilepsy
  • Mesial temporal sclerosis
  • Visual memory

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Jai Jai Shiva Shankar

  • Shivashankar Ravishankar

  • Sanjib Sinha

  • Peruvamba N. Jayakumar

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free