Amiodarone pulmonary toxicity: a patient with three recurrences of pulmonary toxicity and consideration of the probable risk for relapse.

  • Okayasu K
  • Takeda Y
  • Kojima J
 et al. 
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Abstract

A 44-year-old man was treated with amiodarone for dilated cardiomyopathy. After 53 months, he developed amiodarone-induced interstitial pneumonia. Amiodarone treatment was terminated, and the patient was given corticosteroids. These treatments were effective. However, pneumonitis recurred whenever prednisolone was reduced to less than 5 mg per day. Considering the patient's background characteristics, we considered his body mass index (BMI, kg/m(2)) and found his to be high. When four additional patients with amiodarone pulmonary toxicity were reviewed at our institute, a correlation between BMI and the duration of shadow disappearance was found (R(2)=0.8695). Because amiodarone is lipophilic, the patient's high BMI might have influenced the repeated appearance of pulmonary toxicity.

Author-supplied keywords

  • Adult
  • Amiodarone
  • Amiodarone: adverse effects
  • Amiodarone: therapeutic use
  • Anti-Arrhythmia Agents
  • Anti-Arrhythmia Agents: adverse effects
  • Anti-Arrhythmia Agents: therapeutic use
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents: administration & dosage
  • Anti-Inflammatory Agents: therapeutic use
  • Body Mass Index
  • Cardiomyopathy, Dilated
  • Cardiomyopathy, Dilated: drug therapy
  • Cardiomyopathy, Dilated: pathology
  • Dose-Response Relationship, Drug
  • Humans
  • Lung Diseases, Interstitial
  • Lung Diseases, Interstitial: chemically induced
  • Lung Diseases, Interstitial: drug therapy
  • Lung Diseases, Interstitial: radiography
  • Male
  • Prednisolone
  • Prednisolone: administration & dosage
  • Prednisolone: therapeutic use
  • Radiography, Thoracic
  • Recurrence
  • Retreatment
  • Tomography, X-Ray Computed

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Authors

  • Kaori Okayasu

  • Yuichiro Takeda

  • Jun Kojima

  • Atsuto Yoshizawa

  • Nobuyuki Kobayashi

  • Haruhito Sugiyama

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