Amlodipine, felodipine, and isradipine in the treatment of Chinese patients with mild-to-moderate hypertension

  • Cheung B
  • Lau C
  • Wu B
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Abstract

Optimal treatment of hypertension requires the use of effective antihypertensive drugs. Calcium channel blockers are widely used in the treatment of hypertension and appear to be particularly efficacious in ethnic Chinese patients. The aim of this open-label study was to prospectively investigate the efficacy and tolerability of three dihydropyridine calcium channel blockers in sequence, using the same protocol for each. After 2 weeks of placebo treatment, 73 males and 45 females (mean age, 45 ± 10 years; mean weight, 67 ± 10 kg) with essential hypertension (diastolic blood pressure, 95 to 115 mm Hg) were treated with amlodipine (n = 41), felodipine (n = 38), or isradipine (n = 39) for 8 weeks, with dose titration after 4 weeks. Mean seated systolic and diastolic blood pressure decreased by 23/17, 30/17, and 20/15 mm Hg after 8 weeks of treatment with amlodipine, felodipine, and isradipine, respectively. These reductions were all statistically significant. Blood pressure was controlled (defined as diastolic pressure

Author-supplied keywords

  • Amlodipine
  • Calcium channel blockers
  • Dihydropyridines
  • Felodipine
  • Hypertension
  • Isradipine

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Authors

  • Bernard M.Y. Cheung

  • Chu Pak Lau

  • Bi Zhen Wu

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