The amyloid-beta precursor protein: integrating structure with biological function.

  • Reinhard C
  • Hébert S
  • De Strooper B
  • 170

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Abstract

Proteolytic processing of the amyloid-beta precursor protein (APP) generates the Abeta amyloid peptide of Alzheimer's disease. The biological function of APP itself remains, however, unclear. In the current review, we study in detail the different subdomains of APP and try to assign functional significance to particular structures identified in the protein.

Author-supplied keywords

  • Amyloid beta-Protein Precursor
  • Amyloid beta-Protein Precursor: chemistry
  • Amyloid beta-Protein Precursor: physiology
  • Animals
  • Humans
  • Protein Structure, Tertiary
  • Protein Structure, Tertiary: physiology
  • Structure-Activity Relationship

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Authors

  • Constanze Reinhard

  • Sébastien S Hébert

  • Bart De Strooper

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