This 558-page is a part of the series Methods in Molecular Biology and describes methods and protocols in analgesia. The book is organized into thirty nine individually-authored chapters that discuss a variety of topics including alternatives to mammalian pain models such as Caenorhabditis elegans and Drosophila, locomotor activity in a novel environment as a test of inflammatory pain in rats, animal models of orofacial pain, migraine, visceral pain, chronic pain, cold pressor model, value of dental inpaction pain model in drug development, recombinant cell lines stably expressing functional ion channels, RT-PCR analysis of pain genes, linkage analysis and functional evaluation of inherited clinical pain conditions, bone marrow stromal cells and oligonucleotides in pain research, genetic polymorphisms and human sensitivity to opioid analgesics, molecular assays for characterization of alternatively spliced isoforms of the mu-opioid receptor, standardization of pain measurements in clinical trials, pain imaging in the emerging era of molecular medicine, and current and emerging pharmacologic therapies for pain and challenges which still lay ahead in research. The text of the book is written in English and is well indexed by subject with abstracts for all articles and an extensive list of contributors. Users of the book will include neurological researchers and drug developers.
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