Analysis of asbestos bodies in BAL from subjects with particular exposures

  • De Vuyst P
  • Dumortier P
  • Cevenois P
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Abstract

Four patients with asbestos-related diseases and with unusual exposures underwent bronchoalveolar lavage (BAL) for mineralogical analysis. Asbestos bodies (AB) were counted by light microscopy and analyzed by transmission electron microscopy and X-ray energy spectrometry. AB's were found in all cases, after a mean delay from the end of exposure of 27.7 years. Analysis of the core fibers indicated the type of alveolar asbestos burden and was compared with the previous exposures: Pleural plaques due to household exposure to amosite and crocidolite. Pleural plaques due to occult occupational exposure to crocidolite in a coal miner. Asbestosis due to environmental exposure to tremolite in Turkey. Asbestosis, pleural plaques, and peritoneal mesothelioma due to a short, intense exposure to crocidolite. AB counting in BAL and identification of the central fibers by analytical electron microscopy is a useful, non-invasive and reliable method to evaluate the alveolar retention of bio-persistent fibers and to relate them to specific exposures.

Author-supplied keywords

  • asbestos bodies
  • bronchoalveolar lavage
  • mesothelioma
  • occupational disease

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Authors

  • Paul De Vuyst

  • Pascal Dumortier

  • Pierre Alain Cevenois

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