Analysis of an ascidian integrin provides new insight into early evolution of collagen recognition

  • Tulla M
  • Huhtala M
  • Jäälinoja J
 et al. 
  • 18

    Readers

    Mendeley users who have this article in their library.
  • 10

    Citations

    Citations of this article.

Abstract

αI domain integrins have been found in the ascidian Ciona intestinalis. We produced Ciona α1I domain as a recombinant protein. It did not recognize fibril-forming collagens or bind to GFOGER or other similar motifs in triple-helical peptides. No GFOGER motifs were found in Ciona collagens. As Ciona α1I bound to collagen IX, we propose that before the emergence of GFOGER-dependent collagen receptors in vertebrates, αI domain integrins might have been able to bind to collagen with alternative mechanisms. © 2007 Federation of European Biochemical Societies.

Author-supplied keywords

  • Ascidian
  • Collagen
  • Evolution
  • Integrin
  • MIDAS

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text

Authors

  • Mira Tulla

  • Mikko Huhtala

  • Juha Jäälinoja

  • Jarmo Käpylä

  • Richard W. Farndale

  • Leena Ala-Kokko

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free