Analysis of an ascidian integrin provides new insight into early evolution of collagen recognition

  • Tulla M
  • Huhtala M
  • Jäälinoja J
 et al. 
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αI domain integrins have been found in the ascidian Ciona intestinalis. We produced Ciona α1I domain as a recombinant protein. It did not recognize fibril-forming collagens or bind to GFOGER or other similar motifs in triple-helical peptides. No GFOGER motifs were found in Ciona collagens. As Ciona α1I bound to collagen IX, we propose that before the emergence of GFOGER-dependent collagen receptors in vertebrates, αI domain integrins might have been able to bind to collagen with alternative mechanisms. © 2007 Federation of European Biochemical Societies.

Author-supplied keywords

  • Ascidian
  • Collagen
  • Evolution
  • Integrin

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  • Mira Tulla

  • Mikko Huhtala

  • Juha Jäälinoja

  • Jarmo Käpylä

  • Richard W. Farndale

  • Leena Ala-Kokko

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