Analysis of biochemical reactions models with delays

Abstract

Deterministic descriptions of three biochemical reaction channels formerly considered by Bratsun et al. (2005) [19] are studied. These descriptions are based on the mass action law and for the simple protein production with delayed degradation differ from that proposed by Bratsun et al. An explicit solution to this model is calculated. For the model of reaction with negative feedback and delayed production, global stability of a unique positive steady state is proved. According to the models of these two reaction channels considered in the present paper there cannot appear delayed induced oscillations. For the model of reaction with negative feedback, dimerisation and delayed protein production, local stability for a unique positive steady state is shown for some range of parameters. It is also proved that for some range of parameters the destabilisation due to the increasing delay can occur and delayed induced oscillations may appear. © 2010 Elsevier Inc.