Analysis of complex chromosomal rearrangements in adult patients with MDS and AML by multicolor FISH

  • Babicka L
  • Ransdorfova S
  • Brezinova J
 et al. 
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Abstract

We analyzed complex chromosomal aberrations in 37 adult patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) using classical cytogenetic method, FISH with locus-specific probes, multicolor FISH (mFISH) and multicolor banding (mBAND). Unbalanced structural aberrations, leading to a gain or loss of chromosomal material, were frequently observed in bone marrow cells. In 30 patients (81.1%) loss or rearrangement of chromosome 5, 7 and/or 11 was found. The most frequent numerical change was trisomy 8 as expected (detected in six patients-16.2%) and the most frequent breakpoints 5q13, 5q33, 7q31, 10p12, 11q23, 12p13, 17p11 and 21q22 were determined. © 2006 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • AML
  • Complex chromosomal aberrations
  • MDS
  • mBAND
  • mFISH

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Authors

  • Libuse Babicka

  • Sarka Ransdorfova

  • Jana Brezinova

  • Zuzana Zemanova

  • Lenka Sindelarova

  • Magda Siskova

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