Anemia and its relationship to clinical outcome in heart failure

  • Anand I
  • McMurray J
  • Whitmore J
 et al. 
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BACKGROUND: Anemia is often observed in patients with chronic heart failure (CHF), but its implications for patient outcomes are not well understood. The goal of this study was to investigate the relationship between anemia, severity of CHF, and clinical outcomes. METHODS AND RESULTS: Hemoglobin concentration (Hb) was measured in 912 subjects with CHF enrolled in the Randomized Etanercept North American Strategy to Study Antagonism of Cytokines (RENAISSANCE) trial. In a subgroup of 69 subjects, cardiac MRI was performed at randomization and 24 weeks later. Anemia (Hb < or =12.0 g/dL) was present in 12% of subjects. Cox regression analysis indicated that for every 1-g/dL-higher baseline Hb, the risk of mortality was 15.8% lower (P=0.0009) and the risk of mortality or hospitalization for heart failure was 14.2% lower (P

Author-supplied keywords

  • Anemia/*complications
  • Female
  • Follow-Up Studies
  • Heart Failure/*blood/drug therapy/mortality/pathol
  • Heart Ventricles/pathology
  • Hemoglobins/analysis
  • Hospitalization/statistics & numerical data
  • Humans
  • Hypertrophy, Left Ventricular/blood/etiology/patho
  • Immunoglobulin G/therapeutic use
  • Life Tables
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Organ Size
  • Prognosis
  • Proportional Hazards Models
  • Randomized Controlled Trials as Topic
  • Receptors, Tumor Necrosis Factor/therapeutic use
  • Retrospective Studies
  • Severity of Illness Index
  • Treatment Outcome

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  • I Anand

  • J J McMurray

  • J Whitmore

  • M Warren

  • A Pham

  • M A McCamish

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