Animal and human studies with the mitochondria-targeted antioxidant MitoQ

  • Smith R
  • Murphy M
  • 168

    Readers

    Mendeley users who have this article in their library.
  • 225

    Citations

    Citations of this article.

Abstract

As mitochondrial oxidative damage contributes to a wide range of human diseases, antioxidants designed to be accumulated by mitochondria in vivo have been developed. The most extensively studied of these mitochondria-targeted antioxidants is MitoQ, which contains the antioxidant quinone moiety covalently attached to a lipophilic triphenylphosphonium cation. MitoQ has now been used in a range of in vivo studies in rats and mice and in two phase II human trials. Here, we review what has been learned from these animal and human studies with MitoQ.

Author-supplied keywords

  • MitoQ
  • antioxidants
  • mitochondria
  • oxidative damage

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Robin A.J. Smith

  • Michael P. Murphy

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free