Anthropological survey on red cell glutathione peroxidase (GPX1) polymorphism in Central Western Africa: A tentative hypothesis on the interaction between GPX1*2 and Hbβ*S allelic products

  • Destro‐Bisol G
  • Spedini G
  • 9


    Mendeley users who have this article in their library.
  • 7


    Citations of this article.


Phenotype and allele frequencies for erythrocyte glutathione peroxidase (GPX1) polymorphism are reported in the Mbugu and Sango (Central African Republic), Goun (Benin), and Bamileke (Cameroon) ethnic groups. The GPX1*2 allele frequencies (from 0.012 in the Sango to 0.058 in the Bamileke) fit into the range of the data already known for the Subsaharan populations. The value of GPX1*2 for study of the genetic admixture between Negro and Pygmy populations is suggested. Three different unusual GPX1 electrotypes are described. Finally, we hypothesize an interaction between GPX1*2 and Hb beta*S allelic products occurring in the sickle cells infected by Plasmodium falciparum.

Author-supplied keywords

  • Bamileke
  • Goun
  • Mbugu
  • Sango

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Giovanni Destro‐Bisol

  • Gabriella Spedini

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free