Anti-beta2-glycoprotein I antibodies as risk factors for acute myocardial infarction.

  • Ranzolin A
  • Bohn J
  • Norman G
 et al. 
  • 3


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


OBJECTIVE: To determine whether high levels of antibodies against the phospholipid beta2-glycoprotein I (beta2-gpI) cofactor are associated with an increase in the risk of acute myocardial infarction.

METHODS: The study comprised 82 patients with acute myocardial infarction and 82 controls, who were assessed in regard to age, sex, race, hypertension, smoking, previous heart disease, history of diabetes mellitus, and hypercholesterolemia. The following antibodies were detected using immunoassay: anticardiolipin and anti-beta2-gpI IgA, IgG, and IgM. Adjusted odds ratios (OR) for risk factors were obtained through logistic regression.

RESULTS: The mean ages of the cases and controls were, respectively, 57.7 and 51.1 years (P=0.003). Men (P=0.005) and the white race predominated in both groups (P=0.798). Of the risk factors, a history of diabetes (OR=5.3; 95% CI: 1.9 to 14.9; P=0.001) and previous heart disease (OR=4.7; 95% CI: 2.0 to 10.7; P
CONCLUSION: Anti-beta2-gpI IgA antibodies, but not anticardiolipin antibodies, seemed to behave as independent risk factors for myocardial infarction, which may represent a link between autoimmunity and atherosclerosis in patients with acute myocardial infarction.

Author-supplied keywords

  • Adolescent
  • Adult
  • Anti-Idiotypic
  • Anti-Idiotypic: isolation & purificati
  • Anti-Idiotypic: isolation & purification
  • Antibodies
  • Anticardiolipin
  • Anticardiolipin: immunology
  • Antiphospholipid
  • Antiphospholipid: blood
  • Antiphospholipid: isolation & purifica
  • Antiphospholipid: isolation & purification
  • Case-Control Studies
  • Female
  • Glycoproteins
  • Glycoproteins: immunology
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction
  • Myocardial Infarction: immunology
  • Risk Factors
  • acute myocardial infarction
  • anti-beta2-glycoprotein i anti-
  • antiphospholipid antibodies
  • beta 2-Glycoprotein I
  • bodies
  • hospital são lucas da
  • pucrs

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Aline Ranzolin

  • Jussara Marilú Bohn

  • Gary L Norman

  • Euler Manenti

  • Luis Carlos Bodanese

  • Carlos Alberto Von Mühlen

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free