Antigen specific culture of memory-like CD8 T cells for adoptive immunotherapy.

  • Litterman A
  • Zellmer D
  • LaRue R
 et al. 
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Abstract

Cytotoxic T cells are typically expanded ex vivo for adoptive immunotherapy by culture with IL-2. This culture period leads to a differentiated phenotype and acquisition of effector function, as well as a loss of in vivo proliferative capability and anti-tumor efficacy. Here, we report antigen-specific and polyclonal expansion of cytotoxic T cells in a cocktail of cytokines and small molecules that leads to a memory-like phenotype in mouse and human cells even during extended culture, leading to enhanced in vivo expansion and tumor control in mice.

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Authors

  • Adam J Litterman

  • David M Zellmer

  • Rebecca S LaRue

  • Stephen C Jameson

  • David a Largaespada

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