Anti-HMGCR autoantibodies in european patients with autoimmune necrotizing myopathies: Inconstant exposure to statin

  • Allenbach Y
  • Drouot L
  • Rigolet A
 et al. 
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Abstract

Necrotizing autoimmune myopathy (NAM) is a group of acquired myopathies characterized by prominent myofiber necrosis with little or no muscle inflammation. Recently, researchers identified autoantibodies (aAb) against 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in patients with NAM, especially in statin-exposed patients. Here we report what is to our knowledge the first European cohort of patients with NAM.The serum of 206 patients with suspicion of NAM was tested for detection of anti-HMGCR aAb using an addressable laser bead immunoassay. Forty-five patients were found to be anti-HMGCR positive. Their mean age was 48.9 ± 21.9 years and the group was predominantly female (73.3%). Statin exposure was recorded in 44.4% of patients. Almost all patients had a muscular deficit (97.7%), frequently severe (Medical Research Council [MRC] 5 ≤3 in 75.5%). Subacute onset (

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Authors

  • Yves Allenbach

  • Laurent Drouot

  • Aude Rigolet

  • Jean Luc Charuel

  • Fabienne Jouen

  • Norma B. Romero

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