Antileishmanial properties of tropical marine algae extracts

  • Freile-Pelegrín Y
  • Robledo D
  • Chan-Bacab M
 et al. 
  • 18


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Aqueous and organic extracts of twenty-seven species of marine algae (14 species of Rhodophyta, 5 species of Phaeophyta and 8 species of Chlorophyta) collected from the Gulf of Mexico and Caribbean coast of the Yucatan Peninsula (Mexico) were evaluated for their antileishmanial in vitro activity against Leishmania mexicana promastigote forms. The cytotoxicity of these extracts was also assessed using brine shrimp. Organic extracts from Laurencia microcladia (Rhodophyta), Dictyota caribaea, Turbinaria turbinata and Lobophora variegata (Phaeophyta) possessed promising in vitro activity against L. mexicana promastigotes (LC50 values ranging from 10.9 to 49.9 μg/ml). No toxicity of algal extracts against Artemia salina was observed with LC50 ranging from 119 to ≥ 1000 μg/ml. Further studies on bio-guided fractionation, isolation and characterization of pure compounds from these species as well as in vivo experiments are needed and are already in progress. © 2008 Elsevier B.V. All rights reserved.

Author-supplied keywords

  • Cytotoxicity activity
  • Leishmania
  • Marine algae

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Y. Freile-Pelegrín

  • D. Robledo

  • M. J. Chan-Bacab

  • B. O. Ortega-Morales

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free