Antileishmanial properties of tropical marine algae extracts

  • Y. F
  • D. R
  • M.J. C
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Abstract

Aqueous and organic extracts of twenty-seven species of marine algae (14 species of Rhodophyta, 5 species of Phaeophyta and 8 species of Chlorophyta) collected from the Gulf of Mexico and Caribbean coast of the Yucatan Peninsula (Mexico) were evaluated for their antileishmanial in vitro activity against Leishmania mexicana promastigote forms. The cytotoxicity of these extracts was also assessed using brine shrimp. Organic extracts from Laurencia microcladia (Rhodophyta), Dictyota caribaea, Turbinaria turbinata and Lobophora variegata (Phaeophyta) possessed promising in vitro activity against L. mexicana promastigotes (LC50 values ranging from 10.9 to 49.9 mug/ml). No toxicity of algal extracts against Artemia salina was observed with LC50 ranging from 119 to >= 1000 mug/ml. Further studies on bio-guided fractionation, isolation and characterization of pure compounds from these species as well as in vivo experiments are needed and are already in progress. © 2008 Elsevier B.V. All rights reserved.

Author-supplied keywords

  • *Dictyota caribaea
  • *Dictyota caribaea extract/an [Drug Analysis]
  • *Dictyota caribaea extract/dv [Drug Development]
  • *Dictyota caribaea extract/pd [Pharmacology]
  • *Laurencia microcladia
  • *Laurencia microcladia extract/an [Drug Analysis]
  • *Laurencia microcladia extract/dv [Drug Developmen
  • *Laurencia microcladia extract/pd [Pharmacology]
  • *Lobophora variegata extract/an [Drug Analysis]
  • *Lobophora variegata extract/dv [Drug Development]
  • *Lobophora variegata extract/pd [Pharmacology]
  • *Turbinaria turbinata
  • *Turbinaria turbinata extract/an [Drug Analysis]
  • *Turbinaria turbinata extract/dv [Drug Development
  • *Turbinaria turbinata extract/pd [Pharmacology]
  • *alga
  • *antileishmanial agent/an [Drug Analysis]
  • *antileishmanial agent/dv [Drug Development]
  • *antileishmanial agent/pd [Pharmacology]
  • *brown alga
  • *green alga
  • *lobophora variegata
  • *red alga
  • Artemia
  • LC 50
  • Leishmania mexicana
  • Mexico
  • article
  • cytotoxicity
  • evaluation
  • in vitro study
  • nonhuman
  • priority journal
  • promastigote

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Authors

  • Freile-Pelegrin Y.

  • Robledo D.

  • Chan-Bacab M.J.

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