Antimicrobial abietane diterpenoids from Plectranthus elegans

Abstract

Two novel abietane diterpenoids have been isolated from the aerial material of Plectranthus elegans and identified as 11-hydroxy-12-oxo-7,9(11),13-abietatriene and 7α,11-dihydroxy-12-methoxy-8,11,13-abietatriene. Their structures were determined through rigorous use of spectroscopic methods. Both inhibited spore germination of the fungus Cladosporium cucumerinum, in direct bioautography, at a dose of 1 μg. The new diterpenes also inhibited the growth of Gram-positive bacteria, in the concentration range 10-40 μg ml-1 in broth dilution assay. No effect was observed against Gram-negative bacteria. The ecological implications of these findings are discussed. Copyright © 1996 Elsevier Science Ltd. All rights reserved.