Skip to content
Journal article

Antimicrobial and antioxidant activity of kaempferol rhamnoside derivatives from Bryophyllum pinnatum

Joel S, Tatsimo N, Tamokou J, Havyarimana L, Csupor D, Forgo P, Hohmann J, Kuiate J, Tane P...(+9 more)

BMC research control, vol. 5, issue 158 (2012) pp. 1-6

  • 41


    Mendeley users who have this article in their library.
  • 40


    Citations of this article.
  • N/A


    ScienceDirect users who have downloaded this article.
Sign in to save reference


Background: Bryophyllum pinnatum (Lank.) Oken (Crassulaceae) is a perennial succulent herb widely used in traditional medicine to treat many ailments. Its wide range of uses in folk medicine justifies its being called “life plant“ or “resurrection plant“, prompting researchers’ interest. We describe here the isolation and structure elucidation of antimicrobial and/or antioxidant components from the EtOAc extract of B. pinnatum. Results: The methanol extract displayed both antimicrobial activities with minimum inhibitory concentration (MIC) values ranging from 32 to 512 μg/ml and antioxidant property with an IC50 value of 52.48 μg/ml. Its partition enhanced the antimicrobial activity in EtOAc extract (MIC = 16-128 μg/ml) and reduced it in hexane extract (MIC = 256-1024 μg/ml). In addition, this process reduced the antioxidant activity in EtOAc and hexane extracts with IC50 values of 78.11 and 90.04 μg/ml respectively. Fractionation of EtOAc extract gave seven kaempferol rhamnosides, including; kaempferitrin (1), kaempferol 3-O-a-L-(2-acetyl)rhamnopyranoside-7-O-a-L-rhamnopyranoside (2), kaempferol 3-O-a-L-(3-acetyl)rhamnopyranoside-7-O-a-L-rhamnopyranoside (3), kaempferol 3-O-a-L-(4-acetyl) rhamnopyranoside-7-O-a-L-rhamnopyranoside (4), kaempferol 3-O-a-D- glucopyranoside-7-O-a-Lrhamnopyranoside (5), afzelin (6) and a-rhamnoisorobin (7). All these compounds, except 6 were isolated from this plant for the first time. Compound 7 was the most active, with MIC values ranging from 1 to 2 μg/ml and its antioxidant activity (IC50 = 0.71 μg/ml) was higher than that of the reference drug (IC50 = 0.96 μg/ml). Conclusion: These findings demonstrate that Bryophyllum pinnatum and some of its isolated compounds have interesting antimicrobial and antioxidant properties, and therefore confirming the traditional use of B. pinnatum in the treatment of infectious and free radical damages

Author-supplied keywords

  • antimicrobial
  • antioxidant
  • bryophyllum pinnatum
  • crassulaceae
  • inhibitory concentration
  • kaempferol rhamnosides
  • minimum

Find this document

Get full text

Cite this document

Choose a citation style from the tabs below