Antimicrobial drug resistance trends of bacteremia isolates in a rural hospital in southern Mozambique

  • I. M
  • B. S
  • L. M
 et al. 
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Antibiotic resistance in Africa is increasing but insufficiently recognized as a public health problem. However, there are scarce data for antimicrobial resistance trends among bloodstream isolates in sub-Saharan Africa. Antimicrobial drug resistance trends among bacteria isolated from blood of children < 15 years of age admitted to the Manhiça District Hospital in Mozambique during May 2001-April 2006 were monitored by disk diffusion. We documented a linear trend of increasing resistance throughout the study period to chloramphenicol among isolates of Non-typhi Salmonella (P < 0.001), Escherichia coli (P = 0.002), Staphylococcus aureus (P < 0.001), and Haemophilus influenzae (P < 0.001). Increasing resistance to ampicillin was also observed for H. influenzae isolates (P < 0.001). We report trends of increasing resistance among the most frequent etiologies of bacteremia to the most commonly used antibiotics for empirical therapy in this community. Quinolones and third-generation cephalosporines may be needed in the short term to manage community-acquired infections. Copyright © 2010 by The American Society of Tropical Medicine and Hygiene.

Author-supplied keywords

  • Escherichia coli
  • Haemophilus influenzae
  • Mozambique
  • Salmonella
  • Staphylococcus aureus
  • acute gastroenteritis
  • adolescent
  • amoxicillin plus clavulanic acid
  • ampicillin
  • antibiotic resistance
  • article
  • bacteremia
  • bacterium isolate
  • ceftriaxone
  • child
  • chloramphenicol
  • ciprofloxacin
  • cotrimoxazole
  • disk diffusion
  • erythromycin
  • gentamicin
  • human
  • major clinical study
  • meningitis
  • minimum inhibitory concentration
  • nalidixic acid
  • nonhuman
  • oxacillin
  • penicillin G
  • pneumonia
  • preschool child
  • rural health care
  • school child

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  • Mandomando I.

  • Sigaúque B.

  • Morais L.

  • Espasa M.

  • Vallès X.

  • Sacarlal J.

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