Antioxidant and cyclooxygenase activities of fatty acids found in food

  • Henry G
  • Momin R
  • Nair M
 et al. 
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Several commercially available C-8 to C-24 saturated and unsaturated fatty acids (1-29) were assayed for cyclooxygenase-I (COX-I) and cyclooxygenase-II (COX-II) inhibitory and antioxidant activities. Among the saturated fatty acids tested at 60 microg mL(-1), there was an increase in antioxidant activity with increasing chain length from octanoic acid to myristic acid (C-8-C-14) and a decrease thereafter. All unsaturated fatty acids tested at 60 microg mL(-1) showed good antioxidant activity except for undecylenic acid (12), cis-5-dodecenoic acid (13), and nervonic acid (29). The highest inhibitory activities among the saturated fatty acids tested on cyclooxygenase enzymes COX-I and COX-II were observed for decanoic acid to lauric acid (3-5) at 100 microg mL(-1). Similarly, among the unsaturated fatty acids tested, the highest activities were observed for cis-8,11,14-eicosatrienoic acid (25) and cis-13,16-docosadienoic acid (27) at 100 microg mL(-1).

Author-supplied keywords

  • Antiinflammatory
  • Antioxidant
  • Cyclooxygenase
  • Fatty acids
  • Saturated
  • Unsaturated

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  • Muraleedharan NairMichigan State University Department of Horticulture

  • Geneive E. Henry

  • Rafikali A. Momin

  • David L. Dewitt

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