Several commercially available C-8 to C-24 saturated and unsaturated fatty acids (1-29) were assayed for cyclooxygenase-I (COX-I) and cyclooxygenase-II (COX-II) inhibitory and antioxidant activities. Among the saturated fatty acids tested at 60 μg mL-1, there was an increase in antioxidant activity with increasing chain length from octanoic acid to myristic acid (C-8-C-14) and a decrease thereafter. All unsaturated fatty acids tested at 60 μg mL-1 showed good antioxidant activity except for undecylenic acid (12), cis-5-dodecenoic acid (13), and nervonic acid (29). The highest inhibitory activities among the saturated fatty acids tested on cyclooxygenase enzymes COX-I and COX-Il were observed for decanoic acid to lauric acid (3-5) at 100 μg mL-1. Similarly, among the unsaturated fatty acids tested, the highest activities were observed for cis-8,11,14-eicosatrienoic acid (25) and cis-13,16-docosadienoic acid (27) at 100 μg mL-1.
CITATION STYLE
Henry, G. E., Momin, R. A., Nair, M. G., & Dewitt, D. L. (2002). Antioxidant and cyclooxygenase activities of fatty acids found in food. Journal of Agricultural and Food Chemistry, 50(8), 2231–2234. https://doi.org/10.1021/jf0114381
Mendeley helps you to discover research relevant for your work.