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Antioxidant defense and aging in C. elegans: Is the oxidative damage theory of aging wrong?

Gems D, Doonan R ...see all

Cell Cycle, vol. 8, issue 11 (2009) pp. 1681-1687 Published by Taylor and Francis Inc.

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Abstract

The oxidative damage theory of aging once seemed almost proven. Yet recently the buzzards have been assembling in the blue skies above it. New challenges to the theory from work using nematode worms seem set to bring them down to peck at its bones. But is the theory really dead, or does it just need to be modified?

Author-supplied keywords

  • Aging
  • Antioxidant
  • C. elegans
  • Catalase
  • Free radical
  • Nematode
  • Oxidative stress
  • ROS
  • Superoxide dismutase
  • Theory

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Authors

  • David Gems

  • Ryan Doonan

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