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Antioxidant defense and aging in C. elegans: Is the oxidative damage theory of aging wrong?

Gems D, Doonan R...(+2 more)

Cell Cycle, vol. 8, issue 11 (2009) pp. 1681-1687

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Abstract

The oxidative damage theory of aging once seemed almost proven. Yet recently the buzzards have been assembling in the blue skies above it. New challenges to the theory from work using nematode worms seem set to bring them down to peck at its bones. But is the theory really dead, or does it just need to be modified?

Author-supplied keywords

  • Aging
  • Antioxidant
  • C. elegans
  • Catalase
  • Free radical
  • Nematode
  • Oxidative stress
  • ROS
  • Superoxide dismutase
  • Theory

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