Antiretroviral potential of human tripartite motif-5 and related proteins

  • Zhang F
  • Hatziioannou T
  • Perez-Caballero D
 et al. 
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Abstract

TRIM5α is a potent inhibitor of infection by diverse retroviruses and is encoded by one of a large family of TRIM genes. We found that several TRIM motifs among a panel of selected human TRIM proteins (TRIM1, 5, 6, 18, 19, 21 22, 34) could inhibit infection when artificially targeted to an incoming HIV-1 capsid. Conversely, when ectopically expressed as authentic full-length proteins, most lacked activity against a panel of retroviruses. The exceptions were TRIM1, TRIM5 and TRIM34 proteins. Weak but specific inhibition of HIV-2/SIVMAC and EIAV by TRIM34 was noted, and human TRIM5α modestly, but specifically, inhibited an HIV-1 strain carrying a mutation in the cyclophilin binding loop (G89V). Restriction activity observed in ectopic expression assays was sometimes not detectable in corresponding RNAi-based knockdown experiments. However, endogenous owl monkey TRIMCyp potently inhibited an SIVAGM strain. Overall, sporadic examples of intrinsic antiretroviral activity exist in this panel of TRIM proteins. © 2006 Elsevier Inc. All rights reserved.

Author-supplied keywords

  • HIV-1
  • Intrinsic immunity
  • MLV
  • Retrovirus
  • SIV
  • TRIM genes
  • TRIM5

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Authors

  • Fengwen Zhang

  • Theodora Hatziioannou

  • David Perez-Caballero

  • David Derse

  • Paul D. Bieniasz

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