Antitumor , cytotoxic and antioxidant potential of Aster thomsonii extracts

  • Bibi G
  • Ullah N
  • Mannan A
 et al. 
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Abstract

The present investigation deals with biological evaluation of Aster thomsonii. For this purpose, different biological assays of crude methanolic extract (CME) and its fractions that is n-Hexane fraction (NHF) and aqueous fraction (AQF) were carried out. The results of AQF showed maximum brine shrimp cytotoxic activity with ED50 values of 154.69 μg/ml, while the NHF showed significant potato disc antitumor activity with IC50 values of 9.55 μg/ml. Evaluation of both NHF and AQF fractions for sulforhodamine B assay on human cell line HT144 showed IC50 values of 1.10 and 2.82 mg/ml, respectively. While the IC50 of CME and AQF fractions against human cell line H157 were 0.056 and 0.005 mg/ml, respectively. Antioxidant analysis of AQF determined the IC50 values of 31.98 μg/ml. DNA protection assay results of all plant extracts were also appreciating for further investigations but the extracts and their fractions did not show antibacterial activity.

Author-supplied keywords

  • antioxidant
  • antitumor assay
  • assay
  • aster thomsonii
  • brine shrimp toxicity assay
  • dna protection assay
  • sulforhodamine-b assay

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Authors

  • G Bibi

  • N Ullah

  • A Mannan

  • B Mirza

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