Aortic arch curvature and atherosclerosis have overlapping quantitative trait loci in a cross between 129S6/SvEvTac and C57BL/6J apolipoprotein E-null mice

  • Tomita H
  • Zhilicheva S
  • Kim S
 et al. 
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Abstract

Apolipoprotein E-null mice with a 129S6/SvEvTac strain background (129-apoE) develop atherosclerotic plaques faster in the aortic arch but slower in the aortic root than those with a C57BL/6J background (B6-apoE). The shape of the aortic arch also differs in the 2 strains.

Author-supplied keywords

  • Apolipoprotein E-null mice
  • Atherosclerosis
  • Quantitative trait locus
  • Vascular geometry

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Authors

  • Hirofumi Tomita

  • Svetlana Zhilicheva

  • Shinja Kim

  • Nobuyo Maeda

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